# sizing drops of medicine

Bulletin of Pharmacy, vol. 9, no. 10, page 461-462, (October 1895).

Weight of Drops of Various LIQUID MEDICAMENTS.

Frederich Eschbaum has recently made an exhaustive study of the question propounded at the meeting of the German Pharmaceutical Association last year: “Is it possible to obtain from the same liquid, at all times, drops of identical size and weight?” The study is published in full in the Deutsche Medicinische Wochenschaft, from which we extract the following conclusions:

The size and weight of a drop are determined by two circumstances or conditions, viz.: (1) the adhesion existing between the liquid and the glass, and (2) the specific cohesion of the liquid.

In regard to the first condition, the author says: "Drops of uniform size cannot be obtained by uniformity in the size or shape of the neck of the container, since the quantity of liquid in the latter has an influence on the quantity massing itself into the drop. They can be obtained, however, from a burette, and the sharper the point of the latter the smaller the size of the drops; but it is the size of the external circumference of the point of exit which determines the size of the drop.”*

* Quicksilver is the only fluid that forms an exception to this rule. The size of the drops of this substance is determined by the diameter of the opening in the clear.

To demonstrate this proposition, Eschbaum gives the following figures:

 External Diameterof Point of Pipette Weight of a Drop 0.67 Mm 0.0134 Gm. 1.39 Mm 0.0262 3.89 Mm 0.0492 3.07 Mm 0.0522 4.17 Mm 0.0690 6.56 Mm 0.1000 8.32 Mm 0.1260 14.90 Mm 9.2250

SPECIFIC COHESION OF THE LIQUID.

The specific cohesion of various liquids varies within wide bounds, being greatest in water and least in ether, glycerin, and alcohol. To illustrate this, Eschbaum let the liquids drop from a burette of 6.56 Mm. external diameter at 15°C., and found that fifty drops of each named liquid had the following weight:

 Water 5.00 Gm. Glycerin 3.90 Absolute alcohol 1.54 Alcohol, 94° 1.70 Alcohol, dilute, G.P. 1.87 Ether 1.22

The specific cohesion of a fluid is affected by temperature, but, according to our author, in small amounts the variation from this cause is too small to be taken into account practically.

The specific cohesion of a solution of solid substance in a liquid is lower than that of the liquid.

The drops of a solution, all other circumstances being equal, are therefore smaller than those of the menstruum.

The specific cohesion of liquids is therefore in inverse ratio to their specific weight, so that the absolute weight of a drop of a salt solution, for instance, is almost identical with that of a drop of the original menstruum.

All these results demonstrate the absurdity of our present methods, and led Eschbaum to formulate the following proposition for

Rational Dosage by Drops

As a standard of unity, let a pipette be chosen having an external diameter of point of delivery of 6.56 Mm. Such a pipette delivers drops of distilled water weighing 10 centigrammes each, or 10 drops to the gramme; or, of a tincture made of dilute alcohol, 26 drops to the gramme.

While the ordinary medicineĀ·dropper, with a gum bulb, seems to Eschbaum the most convenient for the patient, on account of its inaccuracy and the careless habits of the majority of nurses he advises a measuring apparatus for lay use, described as follows:

The Rational Medicine-Dropper

Take an ordinary medicine-glass, holding from 30 to 60 Cc., and fit it with a bored cork through which passes a strong glass tube from 2½ to 3 cm. long, the inner end of which is even with the lower surface of the cork, and the outer end projects, say a centimeter, from the top of the latter. The delivery point is not drawn to a point, but is so molten as to leave a very small opening in it, while the lower end of the tube is molten only sufficiently to remove the sharp edge—and even this may be omitted. The outer end should have a diameter of 7 to 7½ Mm. (.28 to .30 inch) and be nearly flat, or only slightly rounded at the edges.

The dropper thus formed should be not more than half-filled, and when it is desired to use it it should be grasped in the palm of the hand and turned upside down over the spoon or other receiver. The heat of the hand, expanding the residual air, will slowly drive out several drops, each of exactly the same size. A well made dropper of this sort may be turned upside down and left thus for several minutes without a drop escaping until the hand (or other external source of warmth) is applied.

While the use of the “drop” as a unit of measure in medicine and pharmacy is to be discouraged, and no one is more convinced of the fact than our author, he recognizes the impossibility of reforming the professions all at once, and the futility of such an attempt. He has therefore done the next best thing, and, with most commendable patience and accuracy, worked out a table of the weight of drops of the various medicaments in common use, selections from which we present below. The results presented in the following table were obtained by the use of a burette with aa external diameter of 6.56 Mm. (say .26 or a full quarter of an inch). It is unnecessary to remark that a burette should be firmly held in measuring, as a trembling hand causes the drop to be shaken off the point before it has completely formed.

 Acid, hydrochloric 11 Solution of formaldehyde 16 hydrochloric dilute 10 " iron subacetate 12 phosphoric 10 " iron sesquichloride 9 sulphuric aromatic 25 " potassium arsenite 15 sulphuric dilute 10 Syrup of iodide of iron 10 Amyene hydrate 31 Spirit (alcohol) 29 Amyl nitrate 33 (alcohol (dilute) 27 Bromine 17 Spirit of ether 31 Creosote 19 nitrous ether 29 Chloroform 26 camphor 26 Ether 41 Tinctures prepared with alcohol 29 Ether, acetic 30 Tinctures prepared with dilute alcohol 27 Ether, bromic 29 Tincture ethereal acetate of iron 26 Extracts, narcotic, dissolved, according to solvent, which see 17-20 " ethereal chloride of iron 30 Glycerin 13 " malate of iron 14 Oil of almonds 20 " iodine 29 " anise 20 " musk 21 " caraway 21 " opium (G.P.) 25 " clove 20 " rhubarb, aqueous 14 " cinnamon 21 " rhubarb, vinous 17 " croton 21 " strophanthus 26 " lemon 26 " nux vomica 26 " peppermint 24 valerian 26 " olive 21 valerian, etheric 30 " mustard 22 Vinegar 13 " turpentine, rectified 27 Water of bitter almond 19 paraffin 23 Water, chlorine 10 Paraldehyde 27 Water, distilled 10 Solution of ammonia aromatic 11 Water of camphor, colchicum, ipecac, etc. 17 " ammonia caustic 11 " carbolic acid 18

To the Doctor

In conclusion, Eschbaum gives the following very good advice to the physicians: Either regulate your doses after the information conveyed to you in this table, or, what is better, name the absolute weight or measure of the dose prescribed.